Methods for assessing the dependence of ADC on temperature with DWI on MRI

Methods for assessing the dependence of ADC on temperature with DWI MRI


D.S. Semenov, K.A. Sergunova, E.S. Akhmad, Yu.A. Vasilev.

Practical and Clinical Research Center of Diagnostics and Telemedical Technologies, Department of Health Care of Moscow

Purpose of the study

The purpose of this study is to develop a methodology for assessing the temperature dependence of the measured diffusion coefficient (ICD), calculated whenperforming diffusion-weighted magnetic resonanceimaging (MRI).

Materials and methods

To create different ICDs, physical models of obstructed diffusion were used, which are aqueous solutions of the polymer (polyvinylpyrrolidone) with different concentrations. The temperature of the solutions was measured using a fiber optic temperature measurement system with sensors fixed inside the tubes. The dependence of the change in ICD on temperature was recorded when the EPI sequence was periodically started while the phantom was cooling from 38 °C to 22 °C.


As a result of an experimental study, ICD temperature dependences were obtained for each model of diffusion obstructed. Approbation of the technique showed that in the temperature range allowed in the MRI room by thecurrent regulatory documentation (20-23 °C), the valuesof ICDs can differ by up to 25 %. Calculated approximating coefficients of the dependence of ICD on temperature for the used PVP solutions.


The presented experimental technique allows to increase the efficiency of the procedure of periodicquality control using a phantom for diffusion-weightedmagnetic resonance imaging by introducing a correction factor.


diffusion-weighted magnetic resonance imaging, apparent diffusion coefficient, quality control

Semenov Dmitry Sergeevich E-mail:

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